SF: Moderate physical activity linked to increases in brain metabolism

Brain on Exercise Graphic
Graphic by Men’s Health

Can Exercise Change How Your Brain Works?

A new study suggests that how, and how often, older adults exercise could impact breakdown of glucose in the brain. Decreases in brain metabolism (hypometabolism) have been shown to be a characteristic of Alzheimer’s disease and predictive of cognitive decline and the conversion to Alzheimer’s in older adults. Physical activity has been shown to modulate brain glucose metabolism, but it is unclear what level of intensity and duration may be beneficial.

A recent NIA-supported study from the University of Wisconsin led by Dr. Ozioma Okonkwo found that even moderate physical activity may increase metabolism in brain regions important for learning and memory. The study asked cognitively normal, late-middle age (average age 64 years old) participants to wear an accelerometer for 7 consecutive days to measure daily physical activity. Scientists were then able to determine the amount of time each individual engaged in light (e.g., a slow walk), moderate (e.g., a fast walk), and vigorous activities (e.g., run). The physical activity data were analyzed to determine how they corresponded with glucose metabolism within brain areas that have been demonstrated to be impacted in people with Alzheimer’s.


How Do I Measure Intensity?

There are 2 different ways to measure Intensity – the level of effort (Relative) and the amount of energy (Absolute).

See Measuring Physical Activity for more info.


Increasing levels of engagement in moderate physical activity were associated with increases in cerebral glucose metabolism across all brain regions examined. Vigorous activity showed an increase in metabolism only in the hippocampus (an area important for learning and memory). Light physical activity was not associated with changes in metabolism in any of the brain regions examined. Further, how long one engaged in moderate physical activity impacted the amount of brain glucose metabolism. The more time spent performing moderate level of physical activity (average 43.3 min/day to average 68.1 min/day), the greater the increase in brain glucose metabolism.

Overall, this study adds to encouraging evidence that physical activity may be beneficial for neurometabolic function. Specifically, it makes a critical contribution to the efforts to identify the intensity and duration of physical activity that confer the most advantage for combating Alzheimer’s-related changes in mid-life.


IMPORTANT – please seek the advice of a healthcare professional before to starting an exercise program.


 

So, as you read above, “moderate physical activity may increase metabolism in brain regions important for learning and memory”. While I cannot pretend to understand what the increase of metabolism in the brain means for us, I can understand that exercise is extremely important for our quality of life as we age, for our mind and our bodies. So, if you are inactive, or only slightly active, speak with your doctor about starting an exercise routine that you can stick with. It’s that important and you’re worth it!

If exercising is right for you, be sure to check out our Senior Fitness Exercise page for exercises to try. Pick several you like, print them out and record your progress on the back of the page. Go slowly and be sure to focus on your form and breathing.

See Senior Fitness Exercise page for for information, but here’s an example:

Senior Fitness Exercises

Warm Up
Strength    
Wrist Curl Knee Curl
Balance       
Stand on One Foot Heel-to-Toe Walk
Flexibility
Ankles  Back
Cool Down

We hope you found this article from NIH beneficial. Thank you for taking time out of your day to visit with us today!

 

Source: Moderate physical activity linked to increases in metabolism across brain regions
Reference: Dougherty RJ, et al. Moderate physical activity is associated with cerebral glucose metabolism in adults at risk for Alzheimer’s diseaseJournal of Alzheimer’s Disease. 2017;58:1089–1097.

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Author: Joan E Wilder

We provide information and motivation focused on the importance of physical activity to our quality of life. It is our hope to help people invest in themselves by staying active throughout their lives. It's that important.

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